IL-17 Contributes to Angiogenesis in Rheumatoid Arthritis

Rheumatoid Arthritis IL-17 Contributes to Angiogenesis in

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On hu...

reviews Title : IL 17 A and IL 17 F gene polymorphisms in patients with rheumatoid arthritis

Rheumatoid Arthritis IL-17 Induces Monocyte Migration in

serum levels of il-17, il-4, and infî³ in serbian patients with early rheumatoid arthritis

background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cyt...